Hyposmia in progressive supranuclear palsy
Identifieur interne : 001C45 ( Main/Exploration ); précédent : 001C44; suivant : 001C46Hyposmia in progressive supranuclear palsy
Auteurs : Laura Silveira-Moriyama [Royaume-Uni] ; Graham Hughes [Royaume-Uni] ; Alistair Church [Royaume-Uni] ; Hilary Ayling [Royaume-Uni] ; David R. Williams [Royaume-Uni, Australie] ; Aviva Petrie [Royaume-Uni] ; Janice Holton [Royaume-Uni] ; Tamas Revesz [Royaume-Uni] ; Ann Kingsbury [Royaume-Uni] ; Huw R. Morris [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Humans, Male, Mental Status Schedule, Middle Aged, Nerve Degeneration (etiology), Nerve Degeneration (pathology), Olfaction Disorders (etiology), Olfactory Pathways (pathology), Olfactory Pathways (physiopathology), Parkinson's disease, ROC Curve, Retrospective Studies, Smell (physiology), Supranuclear Palsy, Progressive (complications), UPSIT, olfaction, postmortem analysis, smell.
- MESH :
- complications : Supranuclear Palsy, Progressive.
- etiology : Nerve Degeneration, Olfaction Disorders.
- pathology : Nerve Degeneration, Olfactory Pathways.
- physiology : Smell.
- physiopathology : Olfactory Pathways.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Humans, Male, Mental Status Schedule, Middle Aged, ROC Curve, Retrospective Studies.
Abstract
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP‐P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22688
Affiliations:
- Australie, Royaume-Uni
- Angleterre, Grand Londres
- Londres
- National Hospital for Neurology and Neurosurgery
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Morris</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Cardiff University School of Medicine, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="570">570</biblScope><biblScope unit="page" to="577">577</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F54DF7414A0B7421893A09EA4AD3745400D1D59A</idno><idno type="DOI">10.1002/mds.22688</idno><idno type="ArticleID">MDS22688</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Nerve Degeneration (etiology)</term><term>Nerve Degeneration (pathology)</term><term>Olfaction Disorders (etiology)</term><term>Olfactory Pathways (pathology)</term><term>Olfactory Pathways (physiopathology)</term><term>Parkinson's disease</term><term>ROC Curve</term><term>Retrospective Studies</term><term>Smell (physiology)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>UPSIT</term><term>olfaction</term><term>postmortem analysis</term><term>smell</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Nerve Degeneration</term><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nerve Degeneration</term><term>Olfactory Pathways</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Smell</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Olfactory Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>ROC Curve</term><term>Retrospective Studies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls (P < 0.001) but higher than in PD (P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE (r = 0.44, P = 0.006) but not disease duration (P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale (P = 0.2), or Frontal Assessment Battery (P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP‐P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name></region><name sortKey="Ayling, Hilary" sort="Ayling, Hilary" uniqKey="Ayling H" first="Hilary" last="Ayling">Hilary Ayling</name><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><name sortKey="Church, Alistair" sort="Church, Alistair" uniqKey="Church A" first="Alistair" last="Church">Alistair Church</name><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name><name sortKey="Hughes, Graham" sort="Hughes, Graham" uniqKey="Hughes G" first="Graham" last="Hughes">Graham Hughes</name><name sortKey="Kingsbury, Ann" sort="Kingsbury, Ann" uniqKey="Kingsbury A" first="Ann" last="Kingsbury">Ann Kingsbury</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R." last="Morris">Huw R. Morris</name><name sortKey="Petrie, Aviva" sort="Petrie, Aviva" uniqKey="Petrie A" first="Aviva" last="Petrie">Aviva Petrie</name><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name></country><country name="Australie"><noRegion><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R." last="Williams">David R. Williams</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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